Hemochromatosis Iron Deficiency in Blood Content

Hemochromatosis Iron Deficiency in Blood Content Hemochromatosis (HCC) is disease caused by increased Iron content in the body. People suffering from HCC absorb increased levels of iron from diet. Body has particular difficulty in removing extra iron. Therefore, over period of time iron build up in organs such as heart, liver, pancreas, joints and pituitary gland. Extra iron in organs causes different diseases, and untreated hemochromatosis can be fatal. Iron is nutrient found in many foods. Its primary function is to carry oxygen through hemoglobin to all parts of the body. Normal human body absorbs 10% of the iron for the food in daily diet. However, people with HCC can absorb four times the amount. Since the body cannot excrete the iron, the metal can reach toxic levels in tissues of major organs. Therefore, undiagnosed and untreated HCC dramatically increases the risk for diseases and conditions such as: diabetes mellitus, irregular heartbeat, arthritis, cirrhosis of the liver or liver cancer, depression, impotence, infertility, hypothyroidism, hypogonadism, and cancers. Untreated levels on iron also causes neurodegenerative diseases: epilepsy, Huntingtons disease and multiple sclerosis. The condition can be divided by type influenced by age of onset and by genetic factors. Type -1occurs frequently along with type 4 also referred as ferroportin disease. Men with type 1or type 4 HCC typically develop symptoms between the ages of 40 and 60, whereas the women develop symptoms after menopause. Type 2 is juvenile-onset disorder. Iron builds up in early development but symptoms usually appear in childhood. By the age 20, decreased secretion of sex hormone is prevalent. Females start menstruation in a normal manner, but cycles stop after a few years. Males experience delayed puberty or sex hormone deficiency symptoms such as impotence. If the disorder is untreated, heart disease is evident by the age of 30. Type 3 hemochromatosis is usually intermediate between types 1 and 2. Symptoms usually begin before age 30. Sometimes iron overload begins before birth and theses cases are called neonatal hemochromatosis. This type is characterized by liver damage that is apparent at bi rth or in the first day of life.Symptoms Although, symptoms may occur early in life, first signs of the hereditary hemochromatosis usually appear in midlife between ages of 30 and 50. Hereditary HCC may cause a variety of symptoms such as: fatigue, abdominal pain and impotence, but the most common complaint is joint pain. On the other hand, some people never experience symptoms. Women are more likely to have symptoms after menopause, when they no longer lose iron with menstruation and pregnancy. Early-stage signs and symptoms- of hereditary hemochromatosis typically resemble those of many other common conditions: arthritis in hands, chronic fatigue, loss of sex drive or impotence, abdominal pain, high blood sugar levels, low thyroid function, abnormal liver function tests. Advanced- stage signs and symptoms- of hereditary hemochromatsis develop serious conditions: cirrhosis- marked by irreversible scarring of the liver, liver failure, liver cancer, diabetes, congestive heart failure, cardiac arrhythmia, discolored skin thats bronze or gray in appearance. People at highest risk are people of 25 years of age and the ones that have an immediate family who has hemochrmatosis . Genes related to Hemochoromatsis Mutations in HAMP, HFE, HFE2, SLC40A1 and TFR2 genes causes hemochromatosis. These genes play an important role in regulating the absorption, transport, and storage of iron. Mutation in these genes impair the control of iron absorption during digestion and alter the distribution of iron to other parts of the body. As a result, iron accumulates in tissues and organ. Each type of HCC is caused by mutations in specific genes. Type 1 is caused by mutations in the HFE gene, and type 2 is caused by HFE2 or HAMP gene. Type 3 is caused by TFR2, whereas type 4 is caused by SLC40A1 gene. The cause of neonatal hemochromatosis is unknown. All three types of hemochromatosis are inherited autosomal recessive diseases, which means double copies of the gene have mutations. Parents of an individual usually carries one copy of mutated gene, but do not show any signs or symptoms of the condition. However, type 4 hemochromtosis has gene in cell that is able to cause the disorder. Usually, person that is affected has parent with same condition. Risk factors People at most risk are the one that carry two copies of HFE gene. This is the greatest risk factor for hereditary hemochromatosis. Second, is the family history. If the person have any family member with HCC it is more likely to get it. Third, ethnicity plays important role as well. People of Northern European decent British, Dutch, German, and French have increased probability of hereditary HCC then other ethnic backgrounds. Fourth, being a man increases chances of developing HCC especially at earlier age. Complications Cirrhosis Liver is prone to injury by long term iron overload. It is defined as permanent scarring of the liver that can lead to serious bleeding from dilated veins in esophagus and stomach and severe fluid retention in abdomen. Also toxins that accumulate in the blood can affect mental functioning, leading to confusion and coma. Cirrhosis can be caused from alcohol abuse and hepatitis. Liver cancer a person with cirrhosis and hereditary HCC is at high risk for liver cancer. Diabetes is disease that affects the way body uses glucose. It is considered to be a leading cause of adult blindness that also plays major role in serious health problems like kidney failure and cardiovascular disease. Congestive heart failure is a life threatening condition that occurs when excess iron in heart interferes with its ability to circulate enough blood to meet bodys needs. Untreated congestive heart failure can be fatal, but the condition can be corrected when HCC is treated and excess iron stores are reduced. Abnormal heart rhythms can cause chest pain and lightheadedness. In some instances it can be fatal, and like congestive heart failure it can be reversed with treatment. Pigment changes deposits of iron on the skin cells can turn skin bronze or gray color. Diagnosis Genetic hemochromatosis can be difficult to detect. Early symptoms such as stiff joints and fatigue can result from a number of conditions that are more common than HCC. Iron overload can be detected with two blood tests: Serum transferring saturation test that measures the amount of iron bound to a protein that carries iron in the blood. Transferrin saturation values greater than 45% are considered too high. Serum ferritin test measures the iron in the body. Doctors usually go for serum ferritin test after serum transferring saturation test came high. Many infections and inflammatory conditions other then hereditary HCC can cause elevated feritin, both of these tests are needed to diagnose the disorder. These tests are not part of medical testing. Public Health officials recommend these test if the person is experiencing joint disease, severe fatigue, heart disease, elevated liver enzymes, impotance, and diabetes. Genetic testing discovery of the HCC gene made genetic testing possible. Some doctors advocate universal screening for HFE gene mutation. They believe that HCC is condition that can cause serious complications when its not treated. Liver biopsy In the procedure , a sample of tissue from your liver, using a needle, is removed. The sample is send to the laboratory where the presence of iron as well as liver damage, cirrhosis is observed. Risks of biopsy include bruising, and bleeding. Treatment Blood removal- hemochromatosis is safely and effectively treated by removing blood on a regular basis. The main goal is to reduce iron. The amount of blood drawn depends on age, and overall health.

The Effects of Obsessive Computer Games Playing on Children’s Activities

The effects of obsessive computer games playing on children’s activities. computer games are very popular with children and teenagers because of their extremely entertaining nature. However they are not witout negative effects on their health and developpment. A lot of children, who are attracted by these games, quickly become addicted to them and would spend hours and hours infront of their computers with their eyes glued on the screen and their minds fixed on nothing else. s the game requires sitting and no physical activity children spend increasing amounts of time infront of their computer, which is likely to increase their risk of obesity, backaches , eye and hand injuries, and even heart deseases. Besides, spending a disproportionate amount of time on one leisure activity at the expense of others will cerainly prevent social development. As aresult many children lose touch with their friends and become lonely. ast but not least, in many cases, these games are accused of being responsible for low performance at school since homework is often neglected or undone and many children finally drop out of school. For all these reasons, children should be taught to use computer games safely in order to avoid the types of eye, back, and hand injuries. Besides, parents are advised to control their children's choice of games and to limit the time spent on these games. Finally they should emphasize alternative activities, such as athletics as well as imaginative play so that their children grow up with healthy minds and healthy bodies.

Lifelong Health Benefits of Mandatory Genetic Screenings

Since their development and introduction to the field of medicine more than a century ago, genetic screenings have become incorporated in many fields of healthcare, including reproductive health and cancer prevention. Genetic screening is a method of identifying genetic disorders through the study of an individual’s DNA. They can be used to determine predisposition for various disorders such as Alzheimer’s, breast cancer, and sickle cell anemia. Genetic screenings inform individuals about their state of health and can help them make efficient choices in regard to disease treatments and prevention; however they have not gone without controversy. Many feel that such screenings can cause stigma and discrimination against individuals who have†¦show more content†¦Despite their benefits for individual and public health, genetic screenings can lead to social stigma against those with genetic disorders. Since the introduction of mass genetic tests, there has been a le gal debate about whether or not to release information about an individual’s screening results. On one side of the debate are those who argue that the data from genetic screenings can be used to benefit public health through the development and improvement of treatments and public health policy (Hodge, 2004). However, a prominent opposing side to this debate has focused on the potential for social and even ethnic quarantine if the results of screenings are made public (Atkin, 2003). Though there is a consensus that genetic screening is beneficial in preventing and treating diseases and poor health, many worry that releasing their results can lead to social stigma for individuals of certain minorities simply because of their greater susceptibility to certain health problems (Natowicz and Alper, 1991). 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America Should Pursue Alternative Energy Sources Essay

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